| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OBFC1 (1-368) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STN1 |
| Gene ID: |
79991 |
| Uniprot ID: |
STN1_HUMAN |
| Immunogen Region: |
1-368 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human OBFC1 (NP_079204.2). |
| Immunogen Sequence: |
MQPGSSRCEEETPSLLWGLD PVFLAFAKLYIRDILDMKES RQVPGVFLYNGHPIKQVDVL GTVIGVRERDAFYSYGVDDS TGVINCICWKKLNTESVSAA PSAARELSLTSQLKKLQETI EQKTKIEIGDTIRVRGSIRT YREEREIHATTYYKVDDPVW NIQIARMLELPTIYRKVYDQ PFHSSALEKEEALSNPGALD LPSLTSLLSEKAKEFLMENR VQSFYQQELEMVESLLSLA |
| Function | Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis.it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage.seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication. Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. |
| Protein Name | Cst Complex Subunit Stn1Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1Suppressor Of Cdc Thirteen Homolog |
| Database Links | Reactome: R-HSA-174411Reactome: R-HSA-174430 |
| Cellular Localisation | NucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Cst Complex Subunit Stn1 antibodyAnti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1 antibodyAnti-Suppressor Of Cdc Thirteen Homolog antibodyAnti-STN1 antibodyAnti-OBFC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
