Anti-NRL antibody (40-100 aa) (STJ11106266)

SKU:
STJ11106266
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: NRL
Gene ID: 4901
Uniprot ID: NRL_HUMAN
Immunogen Region: 40-100 aa
Specificity: A synthetic peptide corresponding to a sequence within amino acids 40-100 of human NRL (NP_006168.1).
Immunogen Sequence: GSTPYSSVPPSPTFSEPGMV GATEGTRPGLEELYWLATLQ QQLGAGEALGLSPEEAMELL Q
Tissue Specificity Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
Post Translational Modifications Phosphorylated. Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.
Function Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
Protein Name Neural Retina-Specific Leucine Zipper Protein
Nrl
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Neural Retina-Specific Leucine Zipper Protein antibody
Anti-Nrl antibody
Anti-NRL antibody
Anti-D14S46E antibody

Information sourced from Uniprot.org

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