| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NOTUM |
| Gene ID: | 147111 |
| Uniprot ID: | NOTUM_HUMAN |
| Immunogen Region: | 20-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3). |
| Immunogen Sequence: | SEGRKTWRRRGQQPPPPPRT EAAPAAGQPVESFPLDFTAV EGNMDSFMAQVKSLAQSLYP CSAQQLNEDLRLHLLLNTSV TCNDGSPAGYYLKESRGSRR WLLFLEGGWYCFNRENCDSR YDTMRRLMSSRDWPRTRTGT GILSSQPEENPYWWNANMVF IPYCSSDVWSGASSKSEKNE YAFMGALIIQEVVRELLGRG LSGAKVLLLAGSSAGGTGVL LNVDRVAEQLEKLGYPAIQ |
| Tissue Specificity | Rarely expressed in adult normal tissues. |
| Function | Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. |
| Protein Name | Palmitoleoyl-Protein Carboxylesterase Notum Hnotum |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-5362798 Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Palmitoleoyl-Protein Carboxylesterase Notum antibody Anti-Hnotum antibody Anti-NOTUM antibody Anti-OK antibody Anti-SW-CL.30 antibody |
Information sourced from Uniprot.org
