| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NOTUM (20-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NOTUM |
| Gene ID: |
147111 |
| Uniprot ID: |
NOTUM_HUMAN |
| Immunogen Region: |
20-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3). |
| Immunogen Sequence: |
SEGRKTWRRRGQQPPPPPRT EAAPAAGQPVESFPLDFTAV EGNMDSFMAQVKSLAQSLYP CSAQQLNEDLRLHLLLNTSV TCNDGSPAGYYLKESRGSRR WLLFLEGGWYCFNRENCDSR YDTMRRLMSSRDWPRTRTGT GILSSQPEENPYWWNANMVF IPYCSSDVWSGASSKSEKNE YAFMGALIIQEVVRELLGRG LSGAKVLLLAGSSAGGTGVL LNVDRVAEQLEKLGYPAIQ |
| Tissue Specificity | Rarely expressed in adult normal tissues. |
| Function | Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. |
| Protein Name | Palmitoleoyl-Protein Carboxylesterase NotumHnotum |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-5362798Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Palmitoleoyl-Protein Carboxylesterase Notum antibodyAnti-Hnotum antibodyAnti-NOTUM antibodyAnti-OK antibodyAnti-SW-CL.30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
