| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Mouse/Rat/Bovine/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NMDAR1 C2 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilized |
| Purification: | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: | WB 1:1000 IHC 1:1000-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Grin1 |
| Gene ID: | 24408 |
| Uniprot ID: | NMDZ1_RAT |
| Immunogen: | Synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2 splice variant insert conjugated to KLH. |
| Tissue Specificity | Detected throughout the brain, in brain cortex, cerebellum, thalamus and olfactory bulb. |
| Post Translational Modifications | NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. Forms excitatory glycinergic receptor complexes with GluN3 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1 Glun1 Glutamate Nmda Receptor Subunit Zeta-1 N-Methyl-D-Aspartate Receptor Subunit Nr1 Nmd-R1 |
| Database Links | Reactome: R-RNO-3928662 Reactome: -RNO-438066 Reactome: -RNO-5673001 Reactome: -RNO-8849932 Reactome: -RNO-9609736 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Postsynaptic Cell Membrane Synaptic Cell Membrane Postsynaptic Density Membrane Synaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b Subunit Association With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 1 antibody Anti-Glun1 antibody Anti-Glutamate Nmda Receptor Subunit Zeta-1 antibody Anti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibody Anti-Nmd-R1 antibody Anti-Grin1 antibody Anti-Nmdar1 antibody |
Information sourced from Uniprot.org