| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX2-2 |
| Gene ID: | 4821 |
| Uniprot ID: | NKX22_HUMAN |
| Immunogen Region: | 1-130 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKX2-2 (NP_002500.1). |
| Immunogen Sequence: | MSLTNTKTGFSVKDILDLPD TNDEEGSVAEGPEEENEGPE PAKRAGPLGQGALDAVQSLP LKNPFYDSSDNPYTRWLAST EGLQYSLHGLAAGAPPQDSS SKSPEPSADESPDNDKETPG GGGDAGKKRK |
| Function | Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas. May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter. |
| Protein Name | Homeobox Protein Nkx-2.2Homeobox Protein Nk-2 Homolog B |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-210746 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-2.2 antibodyAnti-Homeobox Protein Nk-2 Homolog B antibodyAnti-NKX2-2 antibodyAnti-NKX2.2 antibodyAnti-NKX2B antibody |
Information sourced from Uniprot.org