| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NGFR |
| Gene ID: | 4804 |
| Uniprot ID: | TNR16_HUMAN |
| Immunogen Region: | 330-427 |
| Specificity: | Recombinant Protein corresponding to a sequence within amino acids 330-427 of human CD271 (NP_002498.1). |
| Immunogen Sequence: | KGDGGLYSSLPPAKREEVEK LLNGSAGDTWRHLAGELGYQ PEHIDSFTHEACPVRALLAS WATQDSATLDALLAALRRIQ RADLVESLCSESTATSPV |
| Post Translational Modifications | N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues. |
| Function | Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 16 Gp80-Lngfr Low Affinity Neurotrophin Receptor P75ntr Low-Affinity Nerve Growth Factor Receptor Ngf Receptor Low-Affinity Nerve Growth Factor Receptor P75ngfr Low-Affinity Nerve Growth Factor Receptor P75ngr P75 Icd Cd Antigen Cd271 |
| Database Links | Reactome: R-HSA-193634 Reactome: R-HSA-193648 Reactome: R-HSA-193670 Reactome: R-HSA-193681 Reactome: R-HSA-193692 Reactome: R-HSA-205017 Reactome: R-HSA-205025 Reactome: R-HSA-205043 Reactome: R-HSA-209543 Reactome: R-HSA-209560 Reactome: R-HSA-209563 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Perikaryon Cell Projection Growth Cone Dendritic Spine |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 16 antibody Anti-Gp80-Lngfr antibody Anti-Low Affinity Neurotrophin Receptor P75ntr antibody Anti-Low-Affinity Nerve Growth Factor Receptor antibody Anti-Ngf Receptor antibody Anti-Low-Affinity Nerve Growth Factor Receptor P75ngfr antibody Anti-Low-Affinity Nerve Growth Factor Receptor P75ngr antibody Anti-P75 Icd antibody Anti-Cd Antigen Cd271 antibody Anti-NGFR antibody Anti-TNFRSF16 antibody |
Information sourced from Uniprot.org