| Tissue Specificity | Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. |
| Post Translational Modifications | N-glycosylated. |
| Function | May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. |
| Protein Name | Nfat Activation Molecule 1Calcineurin/Nfat-Activating Itam-Containing ProteinNfat-Activating Protein With Itam Motif 1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPartially Recruited To Lipid Rafts Upon Bcr Stimulation |
| Alternative Antibody Names | Anti-Nfat Activation Molecule 1 antibodyAnti-Calcineurin/Nfat-Activating Itam-Containing Protein antibodyAnti-Nfat-Activating Protein With Itam Motif 1 antibodyAnti-NFAM1 antibodyAnti-CNAIP antibody |
Information sourced from Uniprot.org
