| Post Translational Modifications | Undergoes 'Lys-29'-linked auto-ubiquitination at Lys-847 and serves as a scaffold for recruiting USP13 to form an NEDD4-USP13 deubiquitination complex. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1. Ubiquitinates DAZAP2, leading to its proteasomal degradation. Ubiquitinates POLR2A. Functions as a platform to recruit USP13 to form an NEDD4-USP13 deubiquitination complex that plays a critical role in cleaving the 'Lys-48'-linked ubiquitin chains of VPS34 and then stabilizing VPS34, thus promoting the formation of autophagosomes. |
| Protein Name | E3 Ubiquitin-Protein Ligase Nedd4Hect-Type E3 Ubiquitin Transferase Nedd4Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4Nedd-4 |
| Database Links | Reactome: R-MMU-1169408Reactome: -MMU-1253288Reactome: -MMU-8948747Reactome: -MMU-8948751Reactome: -MMU-983168 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinPredominantly Cytoplasmic But Also Located In The NucleusRecruited To The Plasma Membrane By Grb10Once Complexed With Grb10 And Igf1rFollows Igf1r InternalizationRemaining Associated With Early EndosomesUncouples From Igf1r-Containing Endosomes Before The Sorting Of The Receptor To The Lysosomal CompartmentMay Be Recruited To Exosomes By Ndfip1 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Nedd4 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Nedd4 antibodyAnti-Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 antibodyAnti-Nedd-4 antibodyAnti-Nedd4 antibodyAnti-Kiaa0093 antibodyAnti-Nedd-4 antibodyAnti-Nedd4-1 antibodyAnti-Nedd4a antibodyAnti-Rpf1 antibody |
Information sourced from Uniprot.org
