| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NAPEPLD |
| Gene ID: |
222236 |
| Uniprot ID: |
NAPEP_HUMAN |
| Specificity: |
This antibody detects endogenous levels of NAPE-PLD at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human NAPE-PLD |
| Function | D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs. |
| Protein Name | N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase DN-Acyl Phosphatidylethanolamine Phospholipase DNape-PldNape-Hydrolyzing Phospholipase D |
| Database Links | Reactome: R-HSA-2466712 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinEarly Endosome MembraneNucleus EnvelopeNucleusNucleoplasmLocalized In The Proximity Of The Cellular Membranes Likely Through Interaction With Membrane Phospholipids |
| Alternative Antibody Names | Anti-N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D antibodyAnti-N-Acyl Phosphatidylethanolamine Phospholipase D antibodyAnti-Nape-Pld antibodyAnti-Nape-Hydrolyzing Phospholipase D antibodyAnti-NAPEPLD antibodyAnti-C7orf18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
