| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Cleaved by caspases during apoptosis. Phosphorylation by IKBKB/IKKB at Ser-209 promotes its proteasome-mediated degradation. Autoacetylated at Lys-136 which stimulates its catalytic activity. |
| Function | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis. |
| Protein Name | N-Alpha-Acetyltransferase 10N-Terminal Acetyltransferase Complex Ard1 Subunit Homolog AHard1Nata Catalytic Subunit Naa10 |
| Cellular Localisation | CytoplasmNucleusAlso Present In The Free Cytosolic And Cytoskeleton-Bound Polysomes |
| Alternative Antibody Names | Anti-N-Alpha-Acetyltransferase 10 antibodyAnti-N-Terminal Acetyltransferase Complex Ard1 Subunit Homolog A antibodyAnti-Hard1 antibodyAnti-Nata Catalytic Subunit Naa10 antibodyAnti-NAA10 antibodyAnti-ARD1 antibodyAnti-ARD1A antibodyAnti-TE2 antibody |
Information sourced from Uniprot.org
