| Post Translational Modifications | Palmitoylated at the C-terminus.palmitoylation promotes localization to the Golgi apparatus. |
| Function | Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers. Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers. |
| Protein Name | Protein MyomakerMyoblast Fusion MakerTransmembrane Protein 226Transmembrane Protein 8c |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneLocalizes On The Plasma Membrane Of MyoblastsWhere It Mediates Myoblasts FusionAlso Localizes In The Golgi Apparatus And Post-Golgi Following PalmitoylationThe Role Of Golgi Localization Is Unclear |
| Alternative Antibody Names | Anti-Protein Myomaker antibodyAnti-Myoblast Fusion Maker antibodyAnti-Transmembrane Protein 226 antibodyAnti-Transmembrane Protein 8c antibodyAnti-MYMK antibodyAnti-TMEM226 antibodyAnti-TMEM8C antibody |
Information sourced from Uniprot.org
