Western blot analysis of extracts of various cell lines, using MMEL1 antibody (STJ117382) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-MMEL1 antibody (350-450) (STJ117382)

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STJ117382
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMEL1
Gene ID: 79258
Uniprot ID: MMEL1_HUMAN
Immunogen Region: 350-450
Specificity: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human MMEL1 (NP_258428.2).
Immunogen Sequence: NWTLFIQTVLSSVKIKLLPD EEVVVYGIPYLQNLENIIDT YSARTIQNYLVWRLVLDRIG SLSQRFKDTRVNYRKALFGT MVEEVRWRECVGYVNSNMEN A
Tissue Specificity Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
Post Translational Modifications N-glycosylated.
Function Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond.
Protein Name Membrane Metallo-Endopeptidase-Like 1
Membrane Metallo-Endopeptidase-Like 2
Nep2(M
Neprilysin Ii
Nepii
Neprilysin-2
Nep2
Nl2 Cleaved Into - Membrane Metallo-Endopeptidase-Like 1 - Soluble Form
Neprilysin-2 Secreted
Nep2(S
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Secreted
A Secreted Form Produced By Proteolytic Cleavage Also Exists
Alternative Antibody Names Anti-Membrane Metallo-Endopeptidase-Like 1 antibody
Anti-Membrane Metallo-Endopeptidase-Like 2 antibody
Anti-Nep2(M antibody
Anti-Neprilysin Ii antibody
Anti-Nepii antibody
Anti-Neprilysin-2 antibody
Anti-Nep2 antibody
Anti-Nl2 Cleaved Into - Membrane Metallo-Endopeptidase-Like 1 - Soluble Form antibody
Anti-Neprilysin-2 Secreted antibody
Anti-Nep2(S antibody
Anti-MMEL1 antibody
Anti-MELL1 antibody
Anti-MMEL2 antibody
Anti-NEP2 antibody

Information sourced from Uniprot.org

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