• Western blot analysis of extracts of various cell lines, using MICB antibody (STJ111844) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
  • Western blot analysis of extracts of various cell lines, using MICB antibody (STJ111844) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

Anti-MICB antibody (23-108) (STJ111844)

SKU:
STJ111844

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MICB (23-108) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MICB
Gene ID: 4277
Uniprot ID: MICB_HUMAN
Immunogen Region: 23-108
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-108 of human MICB (NP_005922.2).
Immunogen Sequence: AEPHSLRYNLMVLSQDGSVQ SGFLAEGHLDGQPFLRYDRQ KRRAKPQGQWAENVLGAKTW DTETEDLTENGQDLRRTLTH IKDQKG
Tissue Specificity Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
Post Translational Modifications Proteolytically cleaved and released from the cell surface of tumor cells.
Function Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Protein Name Mhc Class I Polypeptide-Related Sequence B
Mic-B
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Binding To Human Cytomegalovirus Glycoprotein Ul16 Causes Sequestration In The Endoplasmic Reticulum
Alternative Antibody Names Anti-Mhc Class I Polypeptide-Related Sequence B antibody
Anti-Mic-B antibody
Anti-MICB antibody
Anti-PERB11.2 antibody

Information sourced from Uniprot.org

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