| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MIA3 (1450-1640) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MIA3 |
| Gene ID: |
375056 |
| Uniprot ID: |
TGO1_HUMAN |
| Immunogen Region: |
1450-1640 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1450-1640 of human MIA3 (NP_940953.2). |
| Immunogen Sequence: |
QIKQMMDVSRTQTAISVVEE DLKLLQLKLRASVSTKCNLE DQVKKLEDDRNSLQAAKAGL EDECKTLRQKVEILNELYQQ KEMALQKKLSQEEYERQERE HRLSAADEKAVSAAEEVKTY KRRIEEMEDELQKTERSFKN QIATHEKKAHENWLKARAAE RAIAEEKREAANLRHKLLEL TQKMAMLQEEP |
| Tissue Specificity | Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. |
| Function | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. |
| Protein Name | Transport And Golgi Organization Protein 1 HomologTango1C219-Reactive PeptideD320Melanoma Inhibitory Activity Protein 3 |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-5694530Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinLocalizes At Endoplasmic Reticulum Exit Sites (Eres)Also Known As Transitional Endoplasmic Reticulum (Ter)Sec16a Is Required For Its Proper Localization To EresAfter Loading Of Col7a1 Into Transport CarriersIt Is Not Incorporated Into Copii Carriers And Remains In The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Transport And Golgi Organization Protein 1 Homolog antibodyAnti-Tango1 antibodyAnti-C219-Reactive Peptide antibodyAnti-D320 antibodyAnti-Melanoma Inhibitory Activity Protein 3 antibodyAnti-MIA3 antibodyAnti-KIAA0268 antibodyAnti-TANGO antibodyAnti-UNQ6077 antibodyAnti-PRO20088 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
