| Tissue Specificity | Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney. |
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to proteasomal degradation. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 15Activator-Recruited Cofactor 105 Kda ComponentArc105Ctg Repeat Protein 7aMediator Complex Subunit 15Positive Cofactor 2 Glutamine/Q-Rich-Associated ProteinPc2 Glutamine/Q-Rich-Associated ProteinTpa-Inducible Gene 1 ProteinTig-1Trinucleotide Repeat-Containing Gene 7 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 15 antibodyAnti-Activator-Recruited Cofactor 105 Kda Component antibodyAnti-Arc105 antibodyAnti-Ctg Repeat Protein 7a antibodyAnti-Mediator Complex Subunit 15 antibodyAnti-Positive Cofactor 2 Glutamine/Q-Rich-Associated Protein antibodyAnti-Pc2 Glutamine/Q-Rich-Associated Protein antibodyAnti-Tpa-Inducible Gene 1 Protein antibodyAnti-Tig-1 antibodyAnti-Trinucleotide Repeat-Containing Gene 7 Protein antibodyAnti-MED15 antibodyAnti-ARC105 antibodyAnti-CTG7A antibodyAnti-PCQAP antibodyAnti-TIG1 antibodyAnti-TNRC7 antibody |
Information sourced from Uniprot.org
