Anti-MCOLN3 antibody (90-280 aa) (STJ11106090)

SKU:
STJ11106090
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: MCOLN3
Gene ID: 55283
Uniprot ID: MCLN3_HUMAN
Immunogen Region: 90-280 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 90-280 of human MCOLN3 (NP_060768.8).
Immunogen Sequence: FKEENTIAFKHLFLKGYMDR MDDTYAVYTQSDVYDQLIFA VNQYLQLYNVSVGNHAYENK GTKQSAMAICQHFYKRGNIY PGNDTFDIDPEIETECFFVE PDEPFHIGTPAENKLNLTLD FHRLLTVELQFKLKAINLQT VRHQELPDCYDFTLTITFDN KAHSGRIKISLDNDISIREC KDWHVSGSIQK
Post Translational Modifications N-glycosylated.
Function Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3.
Protein Name Mucolipin-3
Transient Receptor Potential Channel Mucolipin 3
Trpml3
Database Links Reactome: R-HSA-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Late Endosome Membrane
Lysosome Membrane
Cytoplasmic Vesicle
Autophagosome Membrane
Recycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic Pathway
Under Normal Conditions
Only A Very Minor Proportion Is Present At The Cell Membrane
In The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links
Alternative Antibody Names Anti-Mucolipin-3 antibody
Anti-Transient Receptor Potential Channel Mucolipin 3 antibody
Anti-Trpml3 antibody
Anti-MCOLN3 antibody

Information sourced from Uniprot.org