| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCF2L |
| Gene ID: |
23263 |
| Uniprot ID: |
MCF2L_HUMAN |
| Immunogen Region: |
850-980 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4). |
| Immunogen Sequence: |
YEKAPSYSYKQSLNMAAVGI TENVKGDAKKFEIWYNAREE VYIVQAPTPEIKAAWVNEIR KVLTSQLQACREASQHRALE QSQSLPLPAPTSTSPSRGNS RNIKKLEERKTDPLSLEGYV SSAPLTKPPEK |
| Function | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42. |
| Protein Name | Guanine Nucleotide Exchange Factor DbsDbl's Big SisterMcf2-Transforming Sequence-Like Protein |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013408 |
| Cellular Localisation | Isoform 5: CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideIsoform 3: CytoplasmEndomembrane SystemInteraction With Membranes Enriched In Phosphoinositides Is Mediated By The Cral-Trio DomainCytoplasm |
| Alternative Antibody Names | Anti-Guanine Nucleotide Exchange Factor Dbs antibodyAnti-Dbl's Big Sister antibodyAnti-Mcf2-Transforming Sequence-Like Protein antibodyAnti-MCF2L antibodyAnti-KIAA0362 antibodyAnti-OST antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
