| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MBIP |
| Gene ID: | 51562 |
| Uniprot ID: | MBIP1_HUMAN |
| Immunogen Region: | 1-344 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-344 of human MBIP (NP_057670.2). |
| Immunogen Sequence: | MAAATELNRPSSGDRNLERR CRPNLSREVLYEIFRSLHTL VGQLDLRDDVVKITIDWNKL QSLSAFQPALLFSALEQHIL YLQPFLAKLQSPIKEENTTA VEEIGRTEMGNKNEVNDKFS IGDLQEEEKHKESDLRDVKK TQIHFDPEVVQIKAGKAEID RRISAFIERKQAEINENNVR EFCNVIDCNQENSCARTDAI FTPYPGFKSHVKVSRVVNTY GPQTRPEGIPGSGHKPNSM |
| Tissue Specificity | Ubiquitous. High expression seen in the heart and lung. |
| Function | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Protein Name | Map3k12-Binding Inhibitory Protein 1 Mapk Upstream Kinase-Binding Inhibitory Protein Muk-Binding Inhibitory Protein |
| Database Links | Reactome: R-HSA-3214847 Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus Cytoplasm Shows A Cytoplasmic Localization When Coexpressed With Map3k12 |
| Alternative Antibody Names | Anti-Map3k12-Binding Inhibitory Protein 1 antibody Anti-Mapk Upstream Kinase-Binding Inhibitory Protein antibody Anti-Muk-Binding Inhibitory Protein antibody Anti-MBIP antibody Anti-BM-015 antibody |
Information sourced from Uniprot.org