| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MBD6 |
| Gene ID: |
114785 |
| Uniprot ID: |
MBD6_HUMAN |
| Immunogen Region: |
880-980 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 880-980 of human MBD6 (NP_443129.3). |
| Immunogen Sequence: |
PGSRREPGRLALKWGTRGGF NGQMERSPRRTHHWQHNGEL AEGGAEPKDPPPPGPHSEDL KVPPGVVRKSRRGRRRKYNP TRNSNSSRQDITLEPSPTAR A |
| Function | Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability.may promote cancer cell growth. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 6Methyl-Cpg-Binding Protein Mbd6 |
| Database Links | Reactome: R-HSA-5689603 |
| Cellular Localisation | NucleusChromosomeAssociates With Heterochromatin Containing Chromocentres In A Subset Of Cells In A Dna Methylation-Independent MannerLocalizes To Sites Of Dna Damage Independnet Of The Pr-Dub Complex |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 6 antibodyAnti-Methyl-Cpg-Binding Protein Mbd6 antibodyAnti-MBD6 antibodyAnti-KIAA1887 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
