| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MBD1 |
| Gene ID: |
4152 |
| Uniprot ID: |
MBD1_HUMAN |
| Immunogen Region: |
386-655 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 386-655 of human MBD1 (NP_001191065.1). |
| Immunogen Sequence: |
LPSVWSESEDGAGSPPPYRR RKRPSSARRHHLGPTLKPTL ATRTAQPDHTQAPTKQEAGG GFVLPPPGTDLVFLREGASS PVQVPGPVAASTEALLQEAQ CSGLSWVVALPQVKQEKADT QDEWTPGTAVLTSPVLVPGC PSKAVDPGLPSVKQEPPDPE EDKEENKDDSASKLAPEEEA GGAGTPVITEIFSLGGTRFR DTAVWLPSLQGRHSGREDGC KVWETEDTVEPTSTSWNPR |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Sumoylated, sumoylation may increase interaction with ATF7IP. |
| Function | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. |
| Protein Name | Methyl-Cpg-Binding Domain Protein 1Cxxc-Type Zinc Finger Protein 3Methyl-Cpg-Binding Protein Mbd1Protein Containing Methyl-Cpg-Binding Domain 1 |
| Database Links | Reactome: R-HSA-3899300 |
| Cellular Localisation | NucleusNucleus MatrixNucleus SpeckleChromosomeNuclearIn A Punctate PatternAssociated With Euchromatic Regions Of The ChromosomesWith Pericentromeric Regions On Chromosome 1 And With Telomeric Regions From Several Chromosomes |
| Alternative Antibody Names | Anti-Methyl-Cpg-Binding Domain Protein 1 antibodyAnti-Cxxc-Type Zinc Finger Protein 3 antibodyAnti-Methyl-Cpg-Binding Protein Mbd1 antibodyAnti-Protein Containing Methyl-Cpg-Binding Domain 1 antibodyAnti-MBD1 antibodyAnti-CXXC3 antibodyAnti-PCM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
