| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Microtubule-associated serine/threonine-protein kinase 2 (1201-1250 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAST2 |
| Gene ID: | 23139 |
| Uniprot ID: | MAST2_HUMAN |
| Immunogen Region: | 1201-1250 aa |
| Specificity: | MAST205 Polyclonal Antibody detects endogenous levels of MAST205 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MAST2 at the amino acid range 1201-1250 |
| Post Translational Modifications | Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination. |
| Function | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. |
| Protein Name | Microtubule-Associated Serine/Threonine-Protein Kinase 2 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To The Sub-Membranous Area On Interaction With Cdhr2 |
| Alternative Antibody Names | Anti-Microtubule-Associated Serine/Threonine-Protein Kinase 2 antibodyAnti-MAST2 antibodyAnti-KIAA0807 antibodyAnti-MAST205 antibody |
Information sourced from Uniprot.org