| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MARCH-I (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MARCHF1 |
| Gene ID: |
55016 |
| Uniprot ID: |
MARH1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_060393.1 |
| Immunogen Sequence: |
QSRLSVCPSTQD |
| Post Translational Modifications | Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf1Membrane-Associated Ring Finger Protein 1Membrane-Associated Ring-Ch Protein IMarch-IRing Finger Protein 171Ring-Type E3 Ubiquitin Transferase Marchf1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinLysosome MembraneCytoplasmic Vesicle MembraneLate Endosome MembraneEarly Endosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf1 antibodyAnti-Membrane-Associated Ring Finger Protein 1 antibodyAnti-Membrane-Associated Ring-Ch Protein I antibodyAnti-March-I antibodyAnti-Ring Finger Protein 171 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf1 antibodyAnti-MARCHF1 antibodyAnti-MARCH1 antibodyAnti-RNF171 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
