| Post Translational Modifications | Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf1Membrane-Associated Ring Finger Protein 1Membrane-Associated Ring-Ch Protein IMarch-IRing Finger Protein 171Ring-Type E3 Ubiquitin Transferase Marchf1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinLysosome MembraneCytoplasmic Vesicle MembraneLate Endosome MembraneEarly Endosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf1 antibodyAnti-Membrane-Associated Ring Finger Protein 1 antibodyAnti-Membrane-Associated Ring-Ch Protein I antibodyAnti-March-I antibodyAnti-Ring Finger Protein 171 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf1 antibodyAnti-MARCHF1 antibodyAnti-MARCH1 antibodyAnti-RNF171 antibody |
Information sourced from Uniprot.org
