| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP4 |
| Gene ID: | 4134 |
| Uniprot ID: | MAP4_HUMAN |
| Immunogen Region: | 942-1152 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 942-1152 of human MAP4 (NP_002366.2). |
| Immunogen Sequence: | TENIKHQPGGGRAKVEKKTE AAATTRKPESNAVTKTAGPI ASAQKQPAGKVQIVSKKVSY SHIQSKCGSKDNIKHVPGGG NVQIQNKKVDISKVSSKCGS KANIKHKPGGGDVKIESQKL NFKEKAQAKVGSLDNVGHLP AGGAVKTEGGGSEAPLCPGP PAGEEPAISEAAPEAGAPTS ASGLNGHPTLSGGGDQREAQ TLDSQIQETSI |
| Post Translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338. |
| Function | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. |
| Protein Name | Microtubule-Associated Protein 4Map-4 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterRecruitment To Microtubule Is Inhibited By Microtubules Polyglutamylation |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 4 antibodyAnti-Map-4 antibodyAnti-MAP4 antibody |
Information sourced from Uniprot.org