| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LY9 |
| Gene ID: |
4063 |
| Uniprot ID: |
LY9_HUMAN |
| Immunogen Region: |
160-360 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-360 of human LY9 (NP_001248386.1). |
| Immunogen Sequence: |
TMKSVKVSENFSCNITLMCS VKGAEKSVLYSWTPREPHAS ESNGGSILTVSRTPCDPDLP YICTAQNPVSQRSSLPVHVG QFCTDPGASRGGTTGETVVG VLGEPVTLPLALPACRDTEK VVWLFNTSIISKEREEAATA DPLIKSRDPYKNRVWVSSQD CSLKISQLKIEDAGPYHAYV CSEASSVTSMTHVTLLIYRP E |
| Tissue Specificity | Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients. |
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion.the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. |
| Protein Name | T-Lymphocyte Surface Antigen Ly-9Cell Surface Molecule Ly-9Lymphocyte Antigen 9Slam Family Member 3Slamf3Signaling Lymphocytic Activation Molecule 3Cd Antigen Cd229 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-T-Lymphocyte Surface Antigen Ly-9 antibodyAnti-Cell Surface Molecule Ly-9 antibodyAnti-Lymphocyte Antigen 9 antibodyAnti-Slam Family Member 3 antibodyAnti-Slamf3 antibodyAnti-Signaling Lymphocytic Activation Molecule 3 antibodyAnti-Cd Antigen Cd229 antibodyAnti-LY9 antibodyAnti-CDABP0070 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
