| Tissue Specificity | Preferentially expressed in regulatory T-cells (Tregs). |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Activator Lrrc32 antibodyAnti-Garpin antibodyAnti-Glycoprotein A Repetitions Predominant antibodyAnti-Garp antibodyAnti-Leucine-Rich Repeat-Containing Protein 32 antibodyAnti-LRRC32 antibodyAnti-D11S833E antibody |
Information sourced from Uniprot.org
