| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LRRC32 (520-620) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LRRC32 |
| Gene ID: |
2615 |
| Uniprot ID: |
LRC32_HUMAN |
| Immunogen Region: |
520-620 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 520-620 of human LRRC32 (NP_005503.1). |
| Immunogen Sequence: |
NLAENRLSHLPAWTQAVSLE VLDLRNNSFSLLPGSAMGGL ETSLRRLYLQGNPLSCCGNG WLAAQLHQGRVDVDATQDLI CRFSSQEEVSLSHVRPEDCE K |
| Tissue Specificity | Preferentially expressed in regulatory T-cells (Tregs). |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Activator Lrrc32 antibodyAnti-Garpin antibodyAnti-Glycoprotein A Repetitions Predominant antibodyAnti-Garp antibodyAnti-Leucine-Rich Repeat-Containing Protein 32 antibodyAnti-LRRC32 antibodyAnti-D11S833E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
