| Tissue Specificity | Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level). |
| Post Translational Modifications | Palmitoylation of Cys-28 and Cys-31 is required for raft targeting. Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation.which leads to the recruitment of SH2-containing proteins. |
| Function | Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. |
| Protein Name | Lck-Interacting Transmembrane Adapter 1Lck-Interacting Membrane ProteinLck-Interacting Molecule |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid RaftsRecruited To The Immunological Synapse Upon Conjugation Of T-Cell With Antigen-Presenting Cell |
| Alternative Antibody Names | Anti-Lck-Interacting Transmembrane Adapter 1 antibodyAnti-Lck-Interacting Membrane Protein antibodyAnti-Lck-Interacting Molecule antibodyAnti-LIME1 antibodyAnti-LIME antibodyAnti-LP8067 antibody |
Information sourced from Uniprot.org
