| Tissue Specificity | Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. |
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. |
| Protein Name | Lim Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-1234176 |
| Cellular Localisation | CytoplasmNucleusP-BodyCell JunctionAdherens JunctionFocal AdhesionShuttles Between Cytoplasm And Nucleus But Is Localized Predominantly To The CytoplasmFound In The Nucleus But Not NucleoliColocalizes With Vcl In The Focal AdhesionsDown-Regulation And/Or Elimination Of Its Expression From The Nucleus Of Neoplastic Cells Correlates Strongly With Poor Patient Prognosis And Aggressive Forms Of Breast CarcinomaConverselyStrong Nuclear Localization Correlates With Low-Tumor Grade And Better Patient Prognosis |
| Alternative Antibody Names | Anti-Lim Domain-Containing Protein 1 antibodyAnti-LIMD1 antibody |
Information sourced from Uniprot.org
