| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LGALS8 (20-317) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LGALS8 |
| Gene ID: |
3964 |
| Uniprot ID: |
LEG8_HUMAN |
| Immunogen Region: |
20-317 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-317 of human Galectin 8/Galectin 8/LGALS8 (NP_963838.1). |
| Immunogen Sequence: |
VGTIPDQLDPGTLIVIRGHV PSDADRFQVDLQNGSSMKPR ADVAFHFNPRFKRAGCIVCN TLINEKWGREEITYDTPFKR EKSFEIVIMVLKDKFQVAVN GKHTLLYGHRIGPEKIDTLG IYGKVNIHSIGFSFSSDLQS TQASSLELTEISRENVPKSG TPQLRLPFAARLNTPMGPGR TVVVKGEVNANAKSFNVDLL AGKSKDIALHLNPRLNIKAF VRNSFLQESWGEEERNITS |
| Tissue Specificity | Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. |
| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Antibody Names | Anti-Galectin-8 antibodyAnti-Gal-8 antibodyAnti-Po66 Carbohydrate-Binding Protein antibodyAnti-Po66-Cbp antibodyAnti-Prostate Carcinoma Tumor Antigen 1 antibodyAnti-Pcta-1 antibodyAnti-LGALS8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
