Immunohistochemistry analysis of paraffin-embedded Rat testis using LETMD1 Rabbit polyclonal antibody (STJ24397) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-LETMD1 antibody (161-360) (STJ24397)

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STJ24397
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LETMD1
Gene ID: 25875
Uniprot ID: LTMD1_HUMAN
Immunogen Region: 161-360
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 161-360 of human LETMD1 (NP_056231.3).
Immunogen Sequence: FPRQLLIRHFWTPKQQTDFL DIYHAFRKQSHPEIISYLEK VIPLISDAGLRWRLTDLCTK IQRGTHPAIHDILALRECFS NHPLGMNQLQALHVKALSRA MLLTSYLPPPLLRHRLKTHT TVIHQLDKALAKLGIGQLTA QEVKSACYLRGLNSTHIGED RCRTWLGEWLQISCSLKEAE LSLLLHNVVLLSTNYLGTRR
Tissue Specificity Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
Function Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1. May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages. Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Protein Name Letm1 Domain-Containing Protein 1
Cervical Cancer 1 Proto-Oncogene Protein P40
Cervical Cancer Proto-Oncogene 2 Protein
Hccr-1
Hcrr-2
Cellular Localisation Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Nucleus
Mitochondrion Inner Membrane
Alternative Antibody Names Anti-Letm1 Domain-Containing Protein 1 antibody
Anti-Cervical Cancer 1 Proto-Oncogene Protein P40 antibody
Anti-Cervical Cancer Proto-Oncogene 2 Protein antibody
Anti-Hccr-1 antibody
Anti-Hcrr-2 antibody
Anti-LETMD1 antibody

Information sourced from Uniprot.org

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