| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LAGE3 |
| Gene ID: | 8270 |
| Uniprot ID: | LAGE3_HUMAN |
| Immunogen Region: | 1-143 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-143 of human LAGE3 (NP_006005.2). |
| Immunogen Sequence: | MRDADADAGGGADGGDGRGG HSCRGGVDTAAAPAGGAPPA HAPGPGRDAASAARGSRMRP HIFTLSVPFPTPLEAEIAHG SLAPDAEPHQRVVGKDLTVS GRILVVRWKAEDCRLLRISV INFLDQLSLVVRTMQRFGPP VSR |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. |
| Protein Name | Ekc/Keops Complex Subunit Lage3L Antigen Family Member 3Protein Eso-3Protein Itba2 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Lage3 antibodyAnti-L Antigen Family Member 3 antibodyAnti-Protein Eso-3 antibodyAnti-Protein Itba2 antibodyAnti-LAGE3 antibodyAnti-DXS9879E antibodyAnti-ESO3 antibodyAnti-ITBA2 antibody |
Information sourced from Uniprot.org