| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
KLRC2 |
| Gene ID: |
3822 |
| Uniprot ID: |
NKG2C_HUMAN |
| Immunogen Region: |
94-231 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 94-231 of human KLRC2 (NP_002251.2). |
| Immunogen Sequence: |
IPFLEQNNFSPNTRTQKARH CGHCPEEWITYSNSCYYIGK ERRTWEESLLACTSKNSSLL SIDNEEEMKFLASILPSSWI GVFRNSSHHPWVTINGLAFK HKIKDSDNAELNCAVLQVNR LKSAQCGSSMIYHCKHKL |
| Tissue Specificity | Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level). Expressed in alpha-beta T cells subsets (at protein level). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed within NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level). |
| Function | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Protein Name | Nkg2-C Type Ii Integral Membrane ProteinCd159 Antigen-Like Family Member CNk Cell Receptor CNkg2-C-Activating Nk ReceptorCd Antigen Cd159c |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Nkg2-C Type Ii Integral Membrane Protein antibodyAnti-Cd159 Antigen-Like Family Member C antibodyAnti-Nk Cell Receptor C antibodyAnti-Nkg2-C-Activating Nk Receptor antibodyAnti-Cd Antigen Cd159c antibodyAnti-KLRC2 antibodyAnti-NKG2C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
