| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLHL7 |
| Gene ID: | 55975 |
| Uniprot ID: | KLHL7_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human KLHL7 (NP_061334.4). |
| Immunogen Sequence: | QAEPLIQDNPECLKMVISGM RYHLLSPEDREELVDGTRPR RKKHDYRIALFGGSQPQSCR YFNPKDYSWTDIRCPFEKRR DAACVFWDNVVYILGGSQLF P |
| Tissue Specificity | Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. |
| Protein Name | Kelch-Like Protein 7 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Cul3 In Punctate Structures At The Perinuclear Region Of The Cytoplasm |
| Alternative Antibody Names | Anti-Kelch-Like Protein 7 antibodyAnti-KLHL7 antibody |
Information sourced from Uniprot.org