| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | KERA |
| Gene ID: | 11081 |
| Uniprot ID: | KERA_HUMAN |
| Immunogen Region: | 21-352 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-352 of human KERA (NP_008966.1). |
| Immunogen Sequence: | RSVRQVYEVHDSDDWTIHDF ECPMECFCPPSFPTALYCEN RGLKEIPAIPSRIWYLYLQN NLIETIPEKPFENATQLRWI NLNKNKITNYGIEKGALSQL KKLLFLFLEDNELEEVPSPL PRSLEQLQLARNKVSRIPQG TFSNLENLTLLDLQNNKLVD NAFQRDTFKGLKNLMQLNMA KNALRNMPPRLPANTMQLFL DNNSIEGIPENYFNVIPKVA FLRLNHNKLSDEGLPSRGF |
| Tissue Specificity | Cornea (at protein level). Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen. |
| Post Translational Modifications | Binds keratan sulfate chains. |
| Function | May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. |
| Protein Name | KeratocanKtnKeratan Sulfate Proteoglycan Keratocan |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Keratocan antibodyAnti-Ktn antibodyAnti-Keratan Sulfate Proteoglycan Keratocan antibodyAnti-KERA antibodyAnti-SLRR2B antibody |
Information sourced from Uniprot.org