| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNQ5 |
| Gene ID: |
56479 |
| Uniprot ID: |
KCNQ5_HUMAN |
| Immunogen Region: |
624-923 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 624-923 of human KCNQ5 (NP_001153602.1). |
| Immunogen Sequence: |
KGSASALALASFQIPPFECE QTSDYQSPVDSKDLSGSAQN SGCLSRSTSANISRGLQFIL TPNEFSAQTFYALSPTMHSQ ATQVPISQSDGSAVAATNTI ANQINTAPKPAAPTTLQIPP PLPAIKHLPRPETLHPNPAG LQESISDVTTCLVASKENVQ VAQSNLTKDRSMRKSFDMGG ETLLSVCPMVPKDLGKSLSV QNLIRSTEELNIQLSGSESS GSRGSQDFYPKWRESKLFI |
| Tissue Specificity | Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. |
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability. Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 5Kqt-Like 5Potassium Channel Subunit Alpha Kvlqt5Voltage-Gated Potassium Channel Subunit Kv7.5 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 5 antibodyAnti-Kqt-Like 5 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt5 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.5 antibodyAnti-KCNQ5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
