| Function | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening. The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens. Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (Probable). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. |
| Protein Name | Small Conductance Calcium-Activated Potassium Channel Protein 1Sk1Skca 1Skca1Hsk1Kca2.1 |
| Database Links | Reactome: R-HSA-1296052 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Small Conductance Calcium-Activated Potassium Channel Protein 1 antibodyAnti-Sk1 antibodyAnti-Skca 1 antibodyAnti-Skca1 antibodyAnti-Hsk1 antibodyAnti-Kca2.1 antibodyAnti-KCNN1 antibodyAnti-SK antibody |
Information sourced from Uniprot.org
