| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNN1 |
| Gene ID: |
3780 |
| Uniprot ID: |
KCNN1_HUMAN |
| Immunogen Region: |
1-90 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNN1 (NP_002239.2). |
| Immunogen Sequence: |
MNSHSYNGSVGRPLGSGPGA LGRDPPDPEAGHPPQPPHSP GLQVVVAKSEPARPSPGSPR GQPQDQDDDEDDEEDEAGRQ RASGKPSNVG |
| Function | Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening. The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens. Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (Probable). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. |
| Protein Name | Small Conductance Calcium-Activated Potassium Channel Protein 1Sk1Skca 1Skca1Hsk1Kca2.1 |
| Database Links | Reactome: R-HSA-1296052 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Small Conductance Calcium-Activated Potassium Channel Protein 1 antibodyAnti-Sk1 antibodyAnti-Skca 1 antibodyAnti-Skca1 antibodyAnti-Hsk1 antibodyAnti-Kca2.1 antibodyAnti-KCNN1 antibodyAnti-SK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
