| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNMB1 (30-102) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNMB1 |
| Gene ID: |
3779 |
| Uniprot ID: |
KCMB1_HUMAN |
| Immunogen Region: |
30-102 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_004128.1). |
| Immunogen Sequence: |
TYYILVTTVLPLYQKSVWTQ ESKCHLIETNIRDQEELKGK KVPQYPCLWVNVSAAGRWAV LYHTEDTRDQNQQ |
| Tissue Specificity | Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-1Bk Channel Subunit Beta-1BkbetaBkbeta1Hbeta1Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-1Calcium-Activated Potassium Channel Subunit BetaCharybdotoxin Receptor Subunit Beta-1K(Vcabeta-1Maxi K Channel Subunit Beta-1Slo-Beta-1Slo-Beta |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457Reactome: R-HSA-9662360Reactome: R-HSA-9667769 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Beta-1 antibodyAnti-Bk Channel Subunit Beta-1 antibodyAnti-Bkbeta antibodyAnti-Bkbeta1 antibodyAnti-Hbeta1 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-1 antibodyAnti-Calcium-Activated Potassium Channel Subunit Beta antibodyAnti-Charybdotoxin Receptor Subunit Beta-1 antibodyAnti-K(Vcabeta-1 antibodyAnti-Maxi K Channel Subunit Beta-1 antibodyAnti-Slo-Beta-1 antibodyAnti-Slo-Beta antibodyAnti-KCNMB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
