| Tissue Specificity | Predominantly expressed in embryo and adult uterus. Low expression found in kidney, small intestine, lung and heart. Isoform 1: Detected in kidney, thymus, and uterus (at protein level). |
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents. Isoform 2: May inhibit KCNQ4-mediated potassium currents. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 4Mink-Related Peptide 3Mirp3Minimum Potassium Ion Channel-Related Peptide 3Potassium Channel Subunit Beta Mirp3 |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 4 antibodyAnti-Mink-Related Peptide 3 antibodyAnti-Mirp3 antibodyAnti-Minimum Potassium Ion Channel-Related Peptide 3 antibodyAnti-Potassium Channel Subunit Beta Mirp3 antibodyAnti-KCNE4 antibody |
Information sourced from Uniprot.org
