| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase KCMF1 (126-176 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCMF1 |
| Gene ID: |
56888 |
| Uniprot ID: |
KCMF1_HUMAN |
| Immunogen Region: |
126-176 aa |
| Specificity: |
This antibody detects endogenous levels of KCMF1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human KCMF1 at the amino acid range 126-176 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome. Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation. Does not ubiquitinate proteins that are acetylated at the N-terminus. Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy. Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Kcmf1Fgf-Induced In Gastric CancerPotassium Channel Modulatory FactorPcmfZz-Type Zinc Finger-Containing Protein 1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmLate EndosomeLysosome |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Kcmf1 antibodyAnti-Fgf-Induced In Gastric Cancer antibodyAnti-Potassium Channel Modulatory Factor antibodyAnti-Pcmf antibodyAnti-Zz-Type Zinc Finger-Containing Protein 1 antibodyAnti-KCMF1 antibodyAnti-FIGC antibodyAnti-ZZZ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
