Immunofluorescence analysis of U2OS cells using KAT6A Rabbit polyclonal antibody (STJ117202) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-KAT6A antibody (800-1000) (STJ117202)

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STJ117202
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Host: Rabbit
Applications: IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KAT6A
Gene ID: 7994
Uniprot ID: KAT6A_HUMAN
Immunogen Region: 800-1000
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human KAT6A (NP_001092883.1).
Immunogen Sequence: EEPQCQERELEISVGKSVSH ENKEQDSYSVESEKKPEVMA PVSSTRLSKQVLPHDSLPAN SQPSRRGRWGRKNRKTQERF GDKDSKLLLEETSSAPQEQY GECGEKSEATQEQYTESEEQ LVASEEQPSQDGKPDLPKRR LSEGVEPWRGQLKKSPEALK CRLTEGSERLPRRYSEGDRA VLRGFSESSEEEEEPESPRS S
Post Translational Modifications Autoacetylation at Lys-604 is required for proper function. Autoacetylated. Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.
Function Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Protein Name Histone Acetyltransferase Kat6a
Moz - Ybf2/Sas3 - Sas2 And Tip60 Protein 3
Myst-3
Monocytic Leukemia Zinc Finger Protein
Runt-Related Transcription Factor-Binding Protein 2
Zinc Finger Protein 220
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-6804758
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Pml Body
Recruited Into Pml Body After Dna Damage
Alternative Antibody Names Anti-Histone Acetyltransferase Kat6a antibody
Anti-Moz - Ybf2/Sas3 - Sas2 And Tip60 Protein 3 antibody
Anti-Myst-3 antibody
Anti-Monocytic Leukemia Zinc Finger Protein antibody
Anti-Runt-Related Transcription Factor-Binding Protein 2 antibody
Anti-Zinc Finger Protein 220 antibody
Anti-KAT6A antibody
Anti-MOZ antibody
Anti-MYST3 antibody
Anti-RUNXBP2 antibody
Anti-ZNF220 antibody

Information sourced from Uniprot.org

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