| Tissue Specificity | Widely expressed, except in testis where it is expressed at low level. |
| Post Translational Modifications | Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response. |
| Function | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. |
| Protein Name | Junction-Mediating And -Regulatory Protein |
| Database Links | Reactome: R-MMU-6804760 |
| Cellular Localisation | NucleusCytoplasmic VesicleCytoplasmCytoskeletonEndomembrane SystemLipid-AnchorAutophagosome MembraneLocalizes To The Nucleus In Most Cell TypesIn Primary NeutrophilsIt Colocalizes With Actin Filaments At The Leading Edge And Is Excluded From The NucleusLocalization Correlates With MotilityBecause It Moves From The Nucleus To The Cytoplasmic Compartment When Cells Are Differentiated From Nonmotile Cells Into Highly Motile Neutrophil-Like CellsAccumulates In Nucleus Under Dna Damage ConditionsIncreasing P53/Tp53 Transcription Response And Reducing Its Influence On Cell MotilityLocalizes To Cytoplasmic Vesicles Which Associate With Actin Filament And Autophagosomal Membranes Upon Starvation-Induced Autophagy |
| Alternative Antibody Names | Anti-Junction-Mediating And -Regulatory Protein antibodyAnti-Jmy antibody |
Information sourced from Uniprot.org
