| Tissue Specificity | Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. |
| Function | Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy. |
| Protein Name | Interleukin-22 Receptor Subunit Alpha-2Il-22 Receptor Subunit Alpha-2Il-22r-Alpha-2Il-22ra2Cytokine Receptor Class-Ii Member 10Cytokine Receptor Family 2 Member 10Crf2-10Cytokine Receptor Family Type 2 - Soluble 1Crf2-S1Interleukin-22-Binding ProteinIl-22bpIl22bpZcytor16 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-22 Receptor Subunit Alpha-2 antibodyAnti-Il-22 Receptor Subunit Alpha-2 antibodyAnti-Il-22r-Alpha-2 antibodyAnti-Il-22ra2 antibodyAnti-Cytokine Receptor Class-Ii Member 10 antibodyAnti-Cytokine Receptor Family 2 Member 10 antibodyAnti-Crf2-10 antibodyAnti-Cytokine Receptor Family Type 2 - Soluble 1 antibodyAnti-Crf2-S1 antibodyAnti-Interleukin-22-Binding Protein antibodyAnti-Il-22bp antibodyAnti-Il22bp antibodyAnti-Zcytor16 antibodyAnti-IL22RA2 antibodyAnti-UNQ5793 antibodyAnti-PRO19598 antibodyAnti-PRO19822 antibody |
Information sourced from Uniprot.org
