• Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
  • Western blot analysis of mouse-kidney lysate, antibody was diluted at 1000. Secondary antibody was diluted at 1:20000

Anti-IL12B antibody (241-290 aa) (STJ98797)

SKU:
STJ98797

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interleukin-12 subunit beta (241-290 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:500-200
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL12B
Gene ID: 3593
Uniprot ID: IL12B_HUMAN
Immunogen Region: 241-290 aa
Specificity: The antibody detects endogenous IL-12B p40
Immunogen: Synthetic peptide from the human protein at the amino acid range 241-290
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Protein Name Interleukin-12 Subunit Beta
Il-12b
Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit
Clmf P40
Il-12 Subunit P40
Nk Cell Stimulatory Factor Chain 2
Nksf2
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-12 Subunit Beta antibody
Anti-Il-12b antibody
Anti-Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody
Anti-Clmf P40 antibody
Anti-Il-12 Subunit P40 antibody
Anti-Nk Cell Stimulatory Factor Chain 2 antibody
Anti-Nksf2 antibody
Anti-IL12B antibody
Anti-NKSF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance