| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL11 |
| Gene ID: | 3589 |
| Uniprot ID: | IL11_HUMAN |
| Immunogen Region: | 22-199 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-199 of human IL11 (NP_000632.1). |
| Immunogen Sequence: | PGPPPGPPRVSPDPRAELDS TVLLTRSLLADTRQLAAQLR DKFPADGDHNLDSLPTLAMS AGALGALQLPGVLTRLRADL LSYLRHVQWLRRAGGSSLKT LEPELGTLQARLDRLLRRLQ LLMSRLALPQPPPDPPAPPL APPSSAWGGIRAAHAILGGL HLTLDWAVRGLLLLKTRL |
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. |
| Protein Name | Interleukin-11Il-11Adipogenesis Inhibitory FactorAgifOprelvekin |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-11 antibodyAnti-Il-11 antibodyAnti-Adipogenesis Inhibitory Factor antibodyAnti-Agif antibodyAnti-Oprelvekin antibodyAnti-IL11 antibody |
Information sourced from Uniprot.org