| Function | Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 5Ifit-5Interferon-Induced 58 Kda ProteinRetinoic Acid- And Interferon-Inducible 58 Kda ProteinP58 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Cell ProjectionRuffle MembraneColocalized With Rigi At Cell Surface RufflesLocalizes To Actin-Rich Protrusions From The Apical Cell Surface |
| Alternative Antibody Names | Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 5 antibodyAnti-Ifit-5 antibodyAnti-Interferon-Induced 58 Kda Protein antibodyAnti-Retinoic Acid- And Interferon-Inducible 58 Kda Protein antibodyAnti-P58 antibodyAnti-IFIT5 antibodyAnti-ISG58 antibodyAnti-RI58 antibody |
Information sourced from Uniprot.org
