| Tissue Specificity | Expressed in several human brain regions, most prominently in the caudate nucleus. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling. |
| Protein Name | 5-Hydroxytryptamine Receptor 65-Ht-65-Ht6Serotonin Receptor 6 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 6 antibodyAnti-5-Ht-6 antibodyAnti-5-Ht6 antibodyAnti-Serotonin Receptor 6 antibodyAnti-HTR6 antibody |
Information sourced from Uniprot.org
