| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. |
| Protein Name | 5-Hydroxytryptamine Receptor 5a5-Ht-55-Ht-5a5-Ht5aSerotonin Receptor 5a |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 5a antibodyAnti-5-Ht-5 antibodyAnti-5-Ht-5a antibodyAnti-5-Ht5a antibodyAnti-Serotonin Receptor 5a antibodyAnti-HTR5A antibody |
Information sourced from Uniprot.org
