| Tissue Specificity | Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas. |
| Function | Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. |
| Protein Name | Oxidoreductase Htatip230 Kda Hiv-1 Tat-Interacting ProteinHiv-1 Tat-Interactive Protein 2 |
| Cellular Localisation | CytoplasmNucleus Envelope |
| Alternative Antibody Names | Anti-Oxidoreductase Htatip2 antibodyAnti-30 Kda Hiv-1 Tat-Interacting Protein antibodyAnti-Hiv-1 Tat-Interactive Protein 2 antibodyAnti-HTATIP2 antibodyAnti-CC3 antibodyAnti-TIP30 antibody |
Information sourced from Uniprot.org
