| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HSPG2 |
| Gene ID: |
3339 |
| Uniprot ID: |
PGBM_HUMAN |
| Immunogen Region: |
22-195 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-195 of human HSPG2 (NP_005520.4). |
| Immunogen Sequence: |
VTHGLRAYDGLSLPEDIETV TASQMRWTHSYLSDDEDMLA DSISGDDLGSGDLGSGDFQM VYFRALVNFTRSIEYSPQLE DAGSREFREVSEAVVDTLES EYLKIPGDQVVSVVFIKELD GWVFVELDVGSEGNADGAQI QEMLLRVISSGSVASYVTSP QGFQFRRLGTVPQF |
| Tissue Specificity | Detected in cerebrospinal fluid, fibroblasts and urine (at protein level). |
| Post Translational Modifications | Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide. O-glycosylated with core 1 or possibly core 8 glycans. Contains three heparan sulfate chains. Also contains chondroitin sulfate. |
| Function | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. LG3 peptide: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
| Protein Name | Basement Membrane-Specific Heparan Sulfate Proteoglycan Core ProteinHspgPerlecanPlc Cleaved Into - Endorepellin - Lg3 Peptide |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1971475Reactome: R-HSA-2022928Reactome: R-HSA-2024096Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3656237Reactome: R-HSA-3656253Reactome: R-HSA-4420332Reactome: R-HSA-9694614Reactome: R-HSA-975634Reactome: R-HSA-977225Reactome: R-HSA-9820960Reactome: R-HSA-9833110 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement Membrane |
| Alternative Antibody Names | Anti-Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein antibodyAnti-Hspg antibodyAnti-Perlecan antibodyAnti-Plc Cleaved Into - Endorepellin - Lg3 Peptide antibodyAnti-HSPG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
