| Function | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. |
| Protein Name | Protein Hook Homolog 1H-Hook1Hhk1 |
| Cellular Localisation | CytoplasmCytoskeletonLocalizes To Punctate Cytoplasmic Foci Which Do Not Appear To Overlap With Early Or Late EndosomesThe Endoplasmic ReticulumMultivesicular Bodies (Mvbs)LysosomesOr MitochondriaOften Found In Close Association With MicrotubulesDoes Not Associate With The Golgi ComplexDuring SpermiogenesisIt Localizes To The Manchette In Spermatids From Steps 8-10It Is Also Present Between The Microtubule Manchette And The NucleusDuring Manchette ElongationIt Is Preferentially Localized To The Nuclear Ring Of The ManchetteWhereas The Strong Localization To The Manchette DecreasesIn More Mature SpermatidsWhile The Manchette Migrates PosteriorlyIt Localizes To Punctuates SpotsAt Later Stages Of Spermatid DifferentiationThe Punctuate Expression Pattern Is Found At Both The Attachment Site And The Proximal End Of The Elongated ManchetteIn ContrastIt Is Not Present In Mature Spermatozoa |
| Alternative Antibody Names | Anti-Protein Hook Homolog 1 antibodyAnti-H-Hook1 antibodyAnti-Hhk1 antibodyAnti-HOOK1 antibody |
Information sourced from Uniprot.org
