| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HLA-DMB |
| Gene ID: | 3109 |
| Uniprot ID: | DMB_HUMAN |
| Immunogen Region: | 19-218 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-218 of human HLA-DMB (NP_002109.2). |
| Immunogen Sequence: | GGFVAHVESTCLLDDAGTPK DFTYCISFNKDLLTCWDPEE NKMAPCEFGVLNSLANVLSQ HLNQKDTLMQRLRNGLQNCA THTQPFWGSLTNRTRPPSVQ VAKTTPFNTREPVMLACYVW GFYPAEVTITWRKNGKLVMP HSSAHKTAQPNGDWTYQTLS HLALTPSYGDTYTCVVEHTG APEPILRDWTPGLSPMQTLK |
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Dm Beta ChainMhc Class Ii Antigen DmbReally Interesting New Gene 7 Protein |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneLocalizes To Late Endocytic CompartmentAssociates With Lysosome Membranes |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Dm Beta Chain antibodyAnti-Mhc Class Ii Antigen Dmb antibodyAnti-Really Interesting New Gene 7 Protein antibodyAnti-HLA-DMB antibodyAnti-DMB antibodyAnti-RING7 antibody |
Information sourced from Uniprot.org